The conventional wisdom in AI is that the next breakthrough will come from more compute, more data, and larger models. But what if the next leap comes from somewhere else? In this episode, Max Welling—co-founder and CTO of CuspAI and professor at the University of Amsterdam—argues that physics may provide some of the ideas behind the next generation of AI systems. We begin with CuspAI’s work using generative AI to design entirely new materials for semiconductors, batteries, carbon capture, and clean energy. Max explains how foundation models for chemistry, agentic workflows, simulation, and automated experimentation are dramatically accelerating the search for new materials and reshaping scientific discovery. The conversation then broadens into a deeper question. Beyond giving AI new scientific problems to solve, can physics also teach us how to build better AI? Max explores surprising connections between machine learning and thermodynamics, why waves may become a new computational primitive for neural networks, and how concepts like symmetry breaking and statistical physics could inspire AI architectures beyond today’s scaling paradigm. 🗒️ Full show notes: https://twimlai.com/go/774.