Challenges mount as the expedition travels farther down the river. With the end of their journey nowhere in sight, hunger and disease take their toll on the men. Colonel Rondon wonders if members of an indigenous tribe are following them … and waiting to attack. Tensions between the men simmer, until they explode in violence. In the midst of this turmoil, Theodore Roosevelt suffers an injury that initially seems small, but could bring him to the brink of death.

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