During and after the Second Syrian War, Antiochus II was involved in many ongoing events with his smaller neighbors and subordinates. Whether it was intervening in the Cappadocian monarchy, being kept out of Bithynia by threats of a wider war, or granting autonomy to Parthia and Bactria to fight the Parni, the Seleucid Empire was a busy place in the mid-3rd Century BCE.

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