Steve House sits down with Kyle Lefkoff, a rare figure who has lived at the intersection of serious alpinism and venture capital for nearly four decades. From discovering his "mutant gene" for rock climbing as a kid in Atlanta to surviving K2's deadliest season in 1986, from co-founding Array Biopharma (acquired by Pfizer for $12 billion) to serving as founding chairman of AIARE, Kyle shares how the same principles—luck, timing, patience, and pattern recognition—govern success on both big walls and in boardrooms. The conversation explores his philosophy of "where matters," his belief that geography shapes who we can become, and why he chose Boulder as the terrain where he could develop both his athletic and entrepreneurial potential. Kyle reflects on "Slater's Law" (the climb isn't over until the ropes are on the ground), the parallels between powder days and market momentum, and his ultimate legacy: building bridges—between climbers and guides, entrepreneurs and investors, communities and their mountains.

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