Episode Description
Problems with the PREVENT score, a breakthrough in lipid-lowering therapy, a surprising benefit in stroke care, and more thoughts on statins and preventive care of heart disease are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
I PREVENT Score
- PREVENT Equations in Young Adults https://doi.org/10.1016/j.jacc.2025.12.019
- Hospital Readmission Reduction Program for HF
https://pmc.ncbi.nlm.nih.gov/articles/PMC7664458/
II A New Breakthrough in LDL-C Management With an Oral PCSK9 Inhibitor
- CORALreef Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
- CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756
III A Win for the Factor XI Inhibitor Asundexian – OCEANIC Stroke Trial
- OCEANIC-STROKE Slide deck https://clinicaltrialresults.org/wp-content/uploads/2026/02/26-02-02_ISC_OCEANIC-STROKE-primary.pdf
- OCEANIC-AF Study Stopped Early https://www.bayer.com/media/en-us/oceanic-af-study-stopped-early-due-to-lack-of-efficacy/
IV Statin Side Effects
- Assessment of AEs Attributed to Statins -- Meta-analysis https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01578-8/fulltext
- N-of-1 Trial to Assess AEs of Statins https://www.nejm.org/doi/full/10.1056/NEJMc2031173
- When to Start a Statin Is a Decision About Preference -- Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808
V Heart Disease Statistics
- CV Statistics in the US, 2026 https://www.jacc.org/doi/10.1016/j.jacc.2025.12.027
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net