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Weight loss medications are evolving at lightning speed. But once you start digging online, it’s easy to feel unsure about what’s real, what’s safe, and what your options actually are if a medication stops working.

In this episode, I walk you through what’s genuinely on the horizon between 2026–2028, using the clinical data we have right now. We’re talking higher-dose oral Wegovy, more affordable non-refrigerated options, and the triple agonist many people are waiting for, with nearly 29% average weight loss. 

Tune in to find out how these medications work, what the research is showing so far, and why this pipeline offers real hope for anyone managing obesity as a chronic disease.

References

Timeline of upcoming obesity medications

Coloring recommendations:

Alcohol Markers 

Coloring books 

Season 2 of The Obesity Guide: Behind the Curtain Podcast

Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey.

Audio Stamps

00:30 – The importance of building a dopamine menu with non-food hobbies to manage obesity long-term.

06:08 – Staying open to new treatments and pivoting strategies in managing a chronic, lifelong disease.

07:48 – Oral Wegovy coming early 2026 with improved results and affordability.

10:00 – Higher-dose Wegovy subq arriving with 21% average weight loss.

11:50 – Orforglipron: a new non-refrigerated oral GLP-1 option.

12:40 – CagriSema combines semaglutide with amylin for enhanced results.

14:20 – Retatrutide overview and warnings about unregulated versions.

15:

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Not Sure Where to Start With the Podcast? I’ve Got You.

Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.

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