Episode Description
We trace how cellular senescence turns damaged cells into “zombies” that stay alive, stop dividing, and poison nearby tissue with the SASP inflammatory cocktail. We weigh what the best human trials actually show about senolytics and why the next wave of precision therapies may matter more than today’s supplement hype.
• cellular senescence as an active stress state, not “cells getting tired”
• the Hayflick limit, telomeres, and why senescence starts as tumor suppression
• SASP as the driver of tissue damage, bystander effects, and inflammaging
• antagonistic pleiotropy and why SASP can help early-life healing
• immunosenescence as the reason senescent cells accumulate with age
• senolytics and survival pathways that keep senescent cells alive
• dasatinib plus quercetin and the logic of hit-and-run dosing
• Mayo Clinic data suggesting benefits depend on baseline senescent burden
• fisetin osteoarthritis trial and how bioavailability can erase lab promise
• senomorphics that silence SASP when cells are “load bearing”
• precision approaches like suicide gene therapy and senescence-targeted CAR-T
• the “psychoage” question of what longer healthspan does to human urgency
This podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice.
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