Episode Description
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In this episode, I'm doing a full deep dive on Dihexa. A synthetic peptide and nootropic that I think hits the perfect sweet spot for cognitive enhancement.
I break down what Dihexa actually is. How it was developed at Washington State University. And how it works in the brain through the HGF/c-MET pathway to drive synaptogenesis.
I also cover the scandal. The PhD revocation, the retracted papers, and the $14 million in settlements from the biotech company that tried to bring a Dihexa pro-drug to market. Spoiler. The pro-drug didn't really work, but Dihexa itself is a different story.
I walk through the animal studies, the limited human trial data, and what we actually know about safety. Including the cancer pathway concern and why cycling matters.
Then I get into practical dosing. Oral, sublingual, injection, intranasal. What I personally take (10mg oral, three times a week) and why I pair it with Alpha GPC on off days.
If you're curious about nootropics but don't want something that turns you into a robot, this one's for you. I share my honest perspective on where Dihexa fits in the toolkit alongside compounds like Cerebrolysin and P-21.