The Holistic GLP-1 Podcast with Elizabeth McGann

GLP-1 Side Effects Aren't Inevitable: How to Avoid Them (with Dr. Matthea Rentea)

Dec 30, 2025

58 mins

Episode Description

What if I told you that the side effects of nausea, constipation, muscle loss AND burnout on GLP-1s are not inevitable? That in many cases, they're simply a sign the medication is being used the wrong way?

In this week's episode of The Holistic GLP-1 Podcast, I sit down with Dr. Matthea Rentea—a double board-certified obesity medicine physician who is quietly revolutionizing how GLP-1s are used in clinical practice. This is one of the most nuanced, compassionate and empowering conversations we've had about how using GLP-1 medications can be part of a true healing journey—not a crash-and-burn weight loss strategy.

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SHOW NOTES

[ 00:00 ] Introduction

[ 01:20 ] How GLP-1s Changed Obesity Medicine

[ 05:05 ] Why Dr. Rentea Practices Holistic Medicine

[ 06:45 ] Dosing Strategy: Why The "Lowest Effective Dose" Works Best

[ 10:00 ] Carbohydrates, Insulin Resistance & Food Ordering

[ 13:40 ] How to Identify Insulin Resistance Early

[ 16:50 ] Why Side Effects Are Often Preventable

[ 18:40 ] Protein, Fiber & Protecting Muscle and Longevity

[ 22:20 ] Lean Mass vs. Skeletal Muscle Mass

[ 25:20 ] Bone Health, Strength Training & Aging