This week on The Genetics Podcast, Patrick is joined by Dr. Tim Jobson, consultant physician and gastroenterologist at Somerset NHS Foundation Trust and Medical Director of Predictive Health Intelligence (PHI). They discuss the rising burden of metabolic liver disease and how routine clinical data can be used to detect disease earlier and prevent late-stage presentation. They also discuss the LiveWell study, a collaboration between Sano Genetics and PHI, and what it reveals about layering genetics and other data types to improve risk stratification and clinical trial recruitment. 

Show Notes

0:00 Intro to The Genetics Podcast

00:59 Welcome to Tim

01:50 The rise of metabolic liver disease and worsening mortality trends

04:35 Motivation and goals behind the Somerset Liver Improvement Program to address late diagnosis

09:13 Where genetics is already used in liver disease and where it’s still emerging

13:17 Current tools for staging liver disease and the challenge of predicting progression at scale

18:48 How the LiveWell study could improve risk prediction and reshape trial recruitment in liver disease

23:58 Applying longitudinal risk detection beyond liver disease to cardiometabolic and other chronic conditions

26:35 Using subtle changes in routine blood tests to identify cancer risk earlier

28:09 Using existing health data to drive earlier intervention and maximize patient impact

30:05 Expanding beyond liver disease, scaling early detection, and advancing precision medicine

32:18 Closing remarks

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