Paul Offit, MD, director of the Vaccine Education Center at the Children’s Hospital of Philadelphia, joins Josh Israel, MD, and Sean Cavanaugh to discuss the recent decision by the Centers for Disease Control and Prevention (CDC) to move several vaccines (including rotavirus, influenza and COVID-19) from a universal recommendation to shared clinical decision-making. While shared clinical decision making has always been an option for physicians and patients, Offit provides practical tips for clinicians navigating these conversations, advising physicians to be empathetic to patient fears, but also to be passionate in explaining the severe risks of vaccine-preventable diseases.