Meredith sits down with Dr. Steven Hyman – a brain expert at The Broad Institute – for a talk about the meaning of change … and whether it’s actually possible. Are people capable of change – in life and relationships? If so, how? Dr. Hyman explains the plastic brain, how it works, how eating a great sandwich in Chicago can be the best thing ever, and why Meredith once thought she looked like Reese Witherspoon. We also catch up with a very special Love Letters couple.

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