Dr. Read Montague, PhD, is a professor and director of the Center for Human Neuroscience Research at Virginia Tech’s Fralin Biomedical Research Institute and an expert in how dopamine and serotonin shape human learning, motivation and decision-making. We discuss how they impact focused effort in the context of short- and long-term goals of all kinds. Also, how SSRIs and low-effort, high-engagement activities reduce the rewarding properties of dopamine, and how AI algorithms are revolutionizing understanding of the brain.

Episode show notes are available at hubermanlab.com.

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Timestamps

(00:00:00) Read Montague

(00:02:54) Dopamine, Motivation & Learning

(00:08:49) Reward Prediction Error, Expectations

(00:12:24) Sponsors: David & Joovv

(00:14:54) Foraging, Dating, Expectations vs Outcomes; AI

(00:23:36) Dopamine, Expectation, Motivation; Forward Drive; Dopamine "Hits"

(00:29:58) Baseline Dopamine & Fluctuations; Parkinson's Disease

(00:34:36) Movement, Urgency; ADHD, Bee's Dance, Explorer vs Focus Mode

(00:42:29) Sponsor: AG1

(00:43:40) Social Media, ADHD; Explorers vs Task-Based, Combat

(00:50:54) Effort, Learning; Social Media & Phones, Resisting Behaviors

(01:01:36) Serotonin & Dopamine, Opponency, SSRIs

(01:11:21) Hunger, Dopamine; Negative Feedback, Learning, Trauma; Torture

(01:18:34) Drugs of Abuse & High Dopamine

(01:19:48) Sponsor: Function

(01:21:35) Trauma & Dopamine Adaptation

(01:27:34) SSRIs, Dopamine, Positive Experiences

(01:29:50) Deep Brain Stimulation; Measuring Dopamine & Serotonin in Humans

(01:36:16) Sleep; Divorce; Science is a Contact Sport

(01:45:14) Long-Term Motivation, Learning How to Fail, Tool: Kids & Sports

(01:54:14) Sponsor: LMNT

(01:55:34) Meditation, Breathing, Learning; Dopamine as a Currency

(02:04:38) Function of Sleep, Motivation; Time Perception & Dopamine, Tracking Time

(02:13:18) LLMs, AI, Uses & Problem Solving

(02:18:33) Future Projects, Commercial Brain-Machine Interfaces; Concentration

(02:25:57) Dopamine "Hits"?; Depression & Schizophrenia; Quitting

(02:30:17) Dopamine & Serotonin Misunderstandings; Internal Satisfaction; Motivation

(02:35:58) Serotonin Syndrome; Acknowledgements

(02:38:31) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

Disclaimer & Disclosures

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