In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health.

Together, they unpack the complex biochemistry of Vitamin B12, exploring how it supports methylation pathways, homocysteine metabolism, and neurological function. This episode provides clarity on why Vitamin B12 deficiency is often overlooked, how genetic variations can impact B12 utilization, and why choosing the correct form of B12 supplementation is essential for optimal outcomes.

Joanne and James also examine the different forms of Vitamin B12—including methylcobalamin, hydroxocobalamin, adenosylcobalamin, and cyanocobalamin—discussing how each functions in the body and when one may be more appropriate than another.

 The conversation highlights common signs and symptoms of B12 deficiency, from fatigue and brain fog to neurological and mood-related concerns, and offers practical, evidence-informed strategies for assessing and supporting B12 status.

This episode is especially valuable for health practitioners, functional medicine clinicians, and individuals seeking a deeper understanding of how Vitamin B12, genetics, and methylation intersect to influence long-term health.

In This Episode, You’ll Learn:

• Why Vitamin B12 is essential for methylation, detoxification, and neurological health
• The different forms of Vitamin B12 and how they work in the body
• Common and often-missed symptoms of Vitamin B12 deficiency
• How B12 supports homocysteine regulation and cardiovascular health
• How to choose the right B12 supplementation based on individual needs
• The connection between genetics, methylation pathways, and B12 metabolism

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