Casey A. Paleos, MD, a principal investigator and study therapist in psychedelic-assisted therapy, covered his extensive experience with MDMA, psilocybin, and ketamine across research and clinical settings for trauma, depression, and anxiety.

Dr. Paleos detailed the mechanism of psychedelics, explaining that they increase the permeability of the "psychic membrane," allowing individuals to access unresolved trauma for potential healing and growth.

He also introduced Innermost, a public benefit corporation focused on training, education, and research in psychedelic medicine, currently specializing in ketamine work. They also noted the lack of "extremely convincing" large-scale trials to definitively prove the effects of microdosing beyond anecdotal evidence.