Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff’s personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy.

• What changed in the first two weeks: appetite, weight, and energy
• Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels
• Why alcohol and coffee stopped feeling rewarding
• The emerging link between GLP-1s, dopamine, and the brain's reward circuitry
• The trade-off between appetite control and a sense of vitality or spark

This episode is for anyone weighing GLP-1s for themselves, or curious what the drugs are actually like beyond the headlines.

This episode was made possible by:

• CocoaVia:. Use code COMMUNE2026 for 25% off at CocoaVia.com
• LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at ⁠⁠drinklmnt.com/commune⁠⁠.
• Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD
• Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 25% off your order at ⁠⁠vivobarefoot.com/commune⁠⁠.
• Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.