Alzheimer's isn't just a diagnosis that shows up in old age. It's a slow metabolic unraveling that can start decades before the first symptom.

In this episode, Jeff sits down with Dr. David Perlmutter, a board-certified neurologist and author of the new book Brain Defenders (out August 18), to unpack what's really driving Alzheimer's and other neurodegenerative diseases. They get into the brain's own immune system, the microglial cells that either protect or destroy your neurons, and why the beta-amyloid hypothesis may have sent decades of research down the wrong path.

• Why microglia, not amyloid plaques, may be the true driver of brain degeneration
• The link between insulin resistance, blood sugar, and neuroinflammation
• How the gut microbiome and oral health shape the brain's immune response
• Practical diet, sleep, and supplement strategies to protect your brain starting now
  

This episode is for anyone who wants to understand Alzheimer's prevention before symptoms start, and for the millions currently caring for a parent or partner facing cognitive decline.

Preorder Dr. David Perlmutter’s new book “Brain Defenders” at braindefenders.com.

This episode was made possible by:

• CocoaVia:. Use code COMMUNE2026 for 25% off at CocoaVia.com
• LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at ⁠⁠drinklmnt.com/commune⁠⁠.
• Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD
• Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 25% off your order at ⁠⁠vivobarefoot.com/commune⁠⁠.
• Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.