In this first installment of the Frontline Weekend Playlist, hear Dr. Abigail Leibowitz present an update on immune-based cancer therapies from the Annual Leadership Symposium & EM: High Risk – Do Not Miss Conference in Beaver Creek, Colorado. She reviews immune checkpoint inhibitors and CAR T-cell therapy, focusing on the recognition and management of immune-related complications encountered in the ED and highlighting why emergency physicians must understand today’s rapidly evolving oncology treatments.