In this episode of ACEP Frontline, Dr. Ryan Stanton is joined by Dr. Michael McCrea to discuss his Michigan Emergency Medicine Assembly lecture, “2 AM Guideline Updates,” a practical review of recent evidence and guideline changes affecting emergency medicine practice. He highlights key updates in ACLS and PALS, pulmonary embolism risk stratification and disposition, ischemic stroke management, and ACEP’s updated aortic dissection clinical policy, focusing on take-home changes clinicians can apply at the bedside.